|LETTER TO EDITOR
|Year : 2019 | Volume
| Issue : 1 | Page : 52-53
“Boomerang sign” in dengue encephalitis
Priyansh Bhayani1, Sourya Acharya1, Samarth Shukla2
1 Department of Medicine, Jawaharlal Nehru Medical College, DMIMS University, Wardha, Maharashtra, India
2 Department of Pathology, Jawaharlal Nehru Medical College, DMIMS University, Wardha, Maharashtra, India
|Date of Submission||30-Jan-2019|
|Date of Acceptance||31-Jan-2019|
|Date of Web Publication||18-Feb-2019|
Dr. Priyansh Bhayani
Department of Medicine, DMIMS University, Jawaharlal Nehru Medical College, Sawangi, Meghe, Wardha - 442 001, Maharashtra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Bhayani P, Acharya S, Shukla S. “Boomerang sign” in dengue encephalitis. Indian J Med Spec 2019;10:52-3
A 16-year-old female came with complaints of fever for 7 days. On the 6th day of fever, she presented with diplopia and headache. She presented to us with altered sensorium. On examination, she was febrile (100° F), pulse rate of 120 beats/min, and blood pressure 90/60 mmHg. On neurological examination, she had altered sensorium, Glasgow Coma Scale score 10/15, right lateral rectus palsy, and bilateral nystagmus, and Kernig's sign was positive. On abdominal examination, spleen was palpable 4 cm from the left costal margin. Other system examinations were normal.
Cerebrospinal fluid examination was within normal limits. Blood tests for malaria and leptospirosis were negative. Weil–Felix reaction was negative. Dengue immunoglobulin M antibody was positive.
A contrast magnetic resonance imaging of the brain revealed nonenhancing localized restricted diffusion in the splenium part of the corpus callosum on diffusion-weighted imaging, resembling “boomerang sign” [Figure 1]. The patient was managed conservatively which resulted in complete resolution of the sign in 2 weeks.
| Discussion|| |
Transient splenial hyperintensity (TSH) can be noted in multiple conditions, as mentioned in [Table 1]., Dengue encephalitis as a cause of TSH has not been reported in literature. TSH usually presents as one of two characteristic patterns, being either a well-demarcated, oval lesion in the midline within the corpus callosum or a more diffuse, irregular lesion extending throughout the splenium and involving the adjacent hemispheres. The proposed mechanisms implicated include a temporary breakdown of the blood–brain barrier, extrapontine myelinolysis, intramyelinic edema due to inflammation leading to microvascular endothelial injury, direct viral invasion of neurons, and toxicity or hypersensitivity to antiepileptic drugs. The boomerang sign may denote a nonspecific brain injury since its clinical significance is not clear yet. These signs are reversible and disappear within a few weeks. The exact reason for increased predilection of the splenium of the corpus callosum is still not known.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Doherty MJ, Jayadev S, Watson NF, Konchada RS, Hallam DK. Clinical implications of splenium magnetic resonance imaging signal changes. Arch Neurol 2005;62:433-7.
Malhotra HS, Garg RK, Vidhate MR, Sharma PK. Boomerang sign: Clinical significance of transient lesion in splenium of corpus callosum. Ann Indian AcadNeurol 2012;15:151-7.
Bulakbasi N, Kocaoglu M, Tayfun C, Ucoz T. Transient splenial lesion of the corpus callosum in clinically mild influenza-associated encephalitis/encephalopathy. AJNR Am J Neuroradiol 2006;27:1983-6.