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Clinical and laboratory profile of people afflicted with melioidosis: A retrospective study
Ponmaleri Koroth Swapna1, Ramakrishna Pai Jakribettu2, Thomas George3, Ponmaleri Koroth Manoj Kumar4, Manjeshwar Srinath Baliga5
1 Department of General Medicine, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
2 Department of Microbiology, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
3 Department of MBBS Student, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
4 Department of General Medicine, KS Hegde Medical College, Mangalore, Karnataka, India
5 Senior Scientist, Mangalore Institute of Oncology, Pumpwell Circle, Mangalore, Karnataka, India
Correspondence Address:
Dr. Ramakrishna Pai Jakribettu
Department of Microbiology, Father Muller Medical College, Kankanady, Mangalore - 575 002, Karnataka
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/INJMS.INJMS_45_19
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Aim: Melioidosis, caused by Burkholderia pseudomallei, is an important disease in some parts of the developing countries and is now categorized as an emerging infection and a global threat. The present study was carried out to ascertain the alterations on the hematological, hepatic, and renal parameters in the infected people. Materials and Methods: This was a retrospective study and was conducted in a tertiary care hospital in India. Data were analyzed in people who were diagnosed to be infected by B. pseudomallei during January 2010–December 2016. A total of 28 people were included in the study and compared with healthy individuals who were tested negative for any infectious and chronic diseases. Results: The results indicated that the infection caused diverse clinical manifestations such as fever, cough, dyspnea, joint pain, headache, bodyache, weight loss, swelling, and decrease in appetite. There was significant difference in the various hematological and hepatic endpoints, while there was no such difference in the renal function test parameters. Conclusions: For the first time, this study indicates that acute infection with melioidosis causes alterations in hematological and hepatic parameters in people with melioidosis.
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