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Year : 2020  |  Volume : 11  |  Issue : 4  |  Page : 220-222

Nitroimidazole-induced reversible neurotoxicity

Department of Neurology, SAMC and PGI, Indore, Madhya Pradesh, India

Correspondence Address:
Dr. Dinesh Chouksey
A2, Flat 204, Maple Woods, Piplya Kumar, Nipania Main Road, Indore - 452 010, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/INJMS.INJMS_69_20

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The nitroimidazole group of drugs is commonly used in India and worldwide for diarrhea and other indications. People are taking it over the counter for their subsequent problems without consultation, and this is harmful to them on chronic use. Similarly, many indications such as amoebic liver abscess need long-duration therapy of these drugs which may present with its toxic effects. We report two cases of metronidazole and ornidazole overuse presented as central and peripheral nervous system toxicity. The magnetic resonance imaging changes similar to nitroimidazole drug toxicity can be seen in many other diseases, and it needs to correlate with a good history for the diagnosis to avoid unnecessary workup burden to the patient.

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