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Year : 2022  |  Volume : 13  |  Issue : 1  |  Page : 33-36

Immature granulocytes: A novel biomarker of acute pericarditis

Department of Emergency Medicine, Health Science University, Antalya Training and Research Hospital, Antalya, Turkey

Correspondence Address:
Dr. Cihan Bedel
Health Science University Antalya Training and Research Hospital, Kazım Karabekir Street, Muratpaşa 07100, Antalya
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injms.injms_60_21

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Background: Cardiac enzymes and inflammatory biomarkers may be elevated in acute pericarditis (AP); however, there is no current biomarker specific for AP. Immature granulocyte (IG) has been used as a marker of inflammation in many diseases. Therefore, in this study, we aimed to investigate the clinical benefit of IG as a marker in the diagnosis of AP. Methodology: This retrospective study included study participants, who presented to our emergency department with chest pain, and were diagnosed with AP between 1 January 2019 and 1 January 2020. The hemogram and biochemistry parameters of all study participants, which were measured at the time of admission to the emergency department, were recorded. The parameters were compared between the patient and control groups. Results: The study included 32 study participants, who met the inclusion criteria, and 32 control study participants with similar demographic characteristics. The mean age of the study participants with AP was 32.19 ± 14.63 years. The study participants with AP had significantly higher IG values compared to the control group (0.47% ±0.24% vs. 0.26% ±0.1%; P < 0.001). High sensitivity (80%) and specificity (90.6%) were obtained for the prediction of AP at the cut-off value of IG >0.65 as the new parameter. Conclusion: IG, which can be obtained from a simple hemogram test, can be used as a marker for AP.

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