Indian Journal of Medical Specialities

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 13  |  Issue : 3  |  Page : 161--165

Role of cardiac biomarkers in patients of chronic obstructive pulmonary disease with acute exacerbation


RV Raghu1, Govind Mawari2, Naresh Kumar1, Mradul Kumar Daga3, Sachin Gautam1, J Aarthi1, Siddharth Chand1, Nupur Ritchie1, Gunjan Rana1, Shubho Acharya1, Parikshit Sen1, Divyansh Chaudhary1, Pratischtha Kain1, Nishant Garg1, Dhruv Bhoria1 
1 Department of Internal Medicine, Maulana Azad Medical College, New Delhi, India
2 Centre for Occupational and Environment Health, Maulana Azad Medical College, New Delhi, India
3 Department of Internal Medicine and Infectious Disease, Institute of Liver and Biliary Sciences, New Delhi, India

Correspondence Address:
Dr. Mradul Kumar Daga
Internal Medicine and Infectious Disease, Institute of Liver and Biliary Sciences, New Delhi
India

Background: Patients with chronic obstructive pulmonary disease (COPD) often have cardiovascular comorbidities. Patients of COPD with cardiovascular complications tend to have more symptoms and a higher mortality than do patients with COPD alone. There are several cardiac biomarkers such as Troponin-T, creatine phosphokinase-MB (CPK-MB), and N-terminal pro-brain natriuretic peptide (NT-proBNP) which can be used to detect cardiac dysfunction in patients of COPD. Retrospective studies suggest that plasma levels of NT-proBNP and cardiac Troponin-T are often elevated in patients with acute exacerbations of COPD and are associated with increased mortality. Aims and objectives: In this study, we assessed the presence of cardiac dysfunction in patients presenting with acute exacerbation of COPD (AECOPD) by using cardiac biomarkers proBNP, Troponin-T, and CPK-MB. Patients were followed up for 30 days to know the relationship between cardiac dysfunction and outcome in terms of repeated admissions, intensive care units (ICU) admissions, and/or mortality. Methodology: Ninety patients of AECOPD were enrolled in our study. A detailed history was taken and physical examination performed in these patients. All patients in the study were subjected to hematological and biochemical investigations. ProBNP, Troponin-T, and CPK-MB were measured within 48 h of admission as measure of cardiac dysfunction; and outcome was assessed in terms of mortality, ICU admission, and repeated admissions within 30 days of admission. Results: Among the study population, 77.77% had at least one deranged cardiac biomarker, and 18.88% of populations had all the three biomarkers of cardiac dysfunction deranged. 24 out of the 90 participants required ventilatory support in the form of noninvasive or invasive ventilation. 7.14% of the study population had repeated admissions, 24.28% had ICU admissions and 11.43% had mortality. All of them had deranged cardiac biomarkers. There was a significant association between deranged proBNP and ICU admission and mortality (P = 0.0151 and 0.0217, respectively). COPD was more prevalent in the age group of 50–70 years and in males. ProBNP levels were significantly elevated in patients who required ventilatory support (P = 0.003). Conclusions: Cardiac dysfunction is common during exacerbations of COPD and portends a poor prognosis. Cardiac dysfunction was more prevalent in the elderly. Patients with deranged cardiac biomarkers had a greater number of ICU admissions, repeated hospital admissions, and a higher mortality. In the follow-up, elevated proBNP was found to be a strong marker for predicting ICU admission, mortality, and repeated admissions.


How to cite this article:
Raghu R V, Mawari G, Kumar N, Daga MK, Gautam S, Aarthi J, Chand S, Ritchie N, Rana G, Acharya S, Sen P, Chaudhary D, Kain P, Garg N, Bhoria D. Role of cardiac biomarkers in patients of chronic obstructive pulmonary disease with acute exacerbation.Indian J Med Spec 2022;13:161-165


How to cite this URL:
Raghu R V, Mawari G, Kumar N, Daga MK, Gautam S, Aarthi J, Chand S, Ritchie N, Rana G, Acharya S, Sen P, Chaudhary D, Kain P, Garg N, Bhoria D. Role of cardiac biomarkers in patients of chronic obstructive pulmonary disease with acute exacerbation. Indian J Med Spec [serial online] 2022 [cited 2022 Aug 16 ];13:161-165
Available from: http://www.ijms.in/article.asp?issn=0976-2884;year=2022;volume=13;issue=3;spage=161;epage=165;aulast=Raghu;type=0